Attempting to explain the possible origin of SARS-CoV2 by means of its comparative with other coronaviruses using bioinformatics tools
DOI:
https://doi.org/10.59057/iberoleon.20075316.202238501Keywords:
origin, SARS-CoV-2, bioinformatics, comparative genomics, coronaviruses, spikeAbstract
At the end of 2019, the world population was affected by the outbreak of a new virus, called SARS-CoV2, which caused the disease known as COVID-19, declared pandemic in March, 2020. Due to its economic and social impact, the scientific community has worked tirelessly to understand the origin of this virus and its characteristics in order to reduce the risks to health and prevent future outbreaks of new variants. Regarding its origin, theories that ensure coronavirus was created in the laboratory for various purposes, such as regulating the world population, have been inevitable. With the aim of challenging the conspiracy hypotheses without scientific validity that seem convenient or convincing, this article tries to explain, in a simple and informative way, the possible origin of SARS-CoV2 from a scientific point of view, based on the genomics and using computational tools. Supported by bioinformatics, the genomic sequence of SARS-CoV2 is compared with those of other coronaviruses that have previously infected humans or animals, placing main interest in their spikes. The differences or similarities of the sequences allow elucidating the possible origin of the virus.
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Alluwaimi, A. M., Alshubaith, I. H., Al-Ali, A. M. y Abohelaika, S. (2020). The Coronaviruses of Animals and Birds: Their Zoonosis, Vaccines, and Models for SARS-CoV and SARS-CoV2. Frontiers in Veterinary Science, 7. https://doi.org/10.3389/fvets.2020.582287
Andersen, K. G., Rambaut, A., Lipkin, W. I., Holmes, E. C. y Garry, R. F. (2020). The proximal origin of SARS-CoV-2. Nature Medicine, 26(4), 450-452. https://doi.org/10.1038/s41591-020-0820-9
Llorente, A. (2020, 18 de marzo). Qué son los coronavirus, cuántos hay y qué efectos tienen sobre los humanos. BBC Mundo. https://www.bbc.com/mundo/noticias-51921093
Lu, S., Wang, J., Chitsaz, F., Derbyshire, M. K., Geer, R. C., Gonzales, N. R., Gwadz, M., Hurwitz, D. I., Marchler, G. H., Song, J. S., Thanki, N., Yamashita, R. A., Yang, M., Zhang, D., Zheng, C., Lanczycki, C. J. y Marchler-Bauer, A. (2019). CDD/SPARCLE: the conserved domain database in 2020. Nucleic Acids Research, 48(D1), D265-D268. https://doi.org/10.1093/nar/gkz991
Maldonado, L. L., Bertelli, A. M. y Kamenetzky, L. (2021). Molecular features similarities between SARS-CoV-2, SARS, MERS and key human genes could favour the viral infections and trigger collateral effects. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-83595-1
Mingarro, I. (2021, 18 de enero). Los 7 tipos de coronavirus que infectan humanos. National Geographic España. https://www.nationalgeographic.com.es/ciencia/siete-tipos-coronavirus-que-infectan-humanos_15353
National Human Genome Research Institute. (2022). Bioinformática. Glosario parlante de términos genómicos y genéticos. https://www.genome.gov/es/genetics-glossary/Bioinformatica
National Human Genome Research Institute. (2022). Genómica. Glosario parlante de términos genómicos y genéticos. https://www.genome.gov/es/genetics-glossary/Genomica
Nieto, J., Robles, N. R. y Liebana, A. (2011). El sistema renina-angiotensina: ¿hasta dónde se expande?, ¿es posible bloquearlo? Nefrología, 2(5), 48-56. 10.3265/NefrologiaSuplementoExtraordinario.pre2011.Jul.11073
Organización Panamericana de la Salud. (2015). Zoonosis. https://www.paho.org/es/temas/zoonosis
Xia, S., Lan, Q., Su, S., Wang, X., Xu, W., Liu, Z., Zhu, Y., Wang, Q., Lu, L. y Jiang, S. (2020). The role of furin cleavage site in SARSCoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin. Signal transduction and targeted therapy, 5(1), 92. https://doi.org/10.1038/s41392-020-0184-0
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