On the journey to find new treatments for idiopathic pulmonary fibrosis
DOI:
https://doi.org/10.59057/iberoleon.20075316.202440746Keywords:
aging, idiopathic pulmonary fibrosis, extracellular matrix, cell senescence, quality of lifeAbstract
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease of unknown etiology. Current therapeutic options often produce significant side effects and fail to reverse the loss of pulmonary function. This article examines recent advances in the development of more effective treatments, highlighting three innovative approaches: (1) drugs that modulate the mechanical signals of the extracellular matrix, critical for fibrosis progression; (2) therapies targeting senescent cells to either eliminate them or mitigate their impact through senolytics and senomorphics; and (3) new compounds in clinical trials, such as an angiotensin II receptor agonist and a Hedgehog pathway inhibitor, which have shown, for the first time, improvements in lung function with minimal side effects. The article links these therapeutic advances to recent molecular discoveries, underscoring the importance of understanding cellular aging mechanisms, such as senescence and mitochondrial dysfunction, in the pathogenesis of IPF. Furthermore, it explores how these findings can translate into safer and more effective pharmacological options. By integrating basic and clinical perspectives, the text provides a comprehensive view of IPF and proposes new therapeutic horizons focused on improving patients’ quality of life. This work contributes to the scientific dialogue on the disease and suggests promising paths for research and treatment.
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